Hepatic expression of CLEC4M is associated with decreased plasma levels of VWF. (A) Plasma levels of VWF in mice expressing CLEC4M in >10% hepatocytes (N = 16). (B) Confirmation of CLEC4M expression by immunohistochemistry studies. (C) CLEC4M-Fc binds recombinant murine VWF in a glycan-dependent manner. ± SE, *P < .05.