Bleeding during EXTEND. Shaded area indicates assessments of ≤ 15 patients. Bleeding was measured using the WHO scale. BL indicates baseline. ^aData shown do not include all assessments; the time points included here illustrate median bleeding scores for the first several weeks of treatment and then at regular intervals thereafter. Patients enrolled in EXTEND at different time points and consequently have differing assessment schedules; therefore, not all patients on study were assessed during each assessment shown. ^bTotal patients on study at weeks 26, 52, 104, and 156.