Outcomes after treatment with banked VSTs: AdV-infected patients. (A) Serial viral load measurements before and during 6 weeks post-VST infusion in 17 evaluable patients (responders and nonresponders) treated for persistent AdV. Results are presented as copies per milliliter, where Adv was detected either in blood or in the stool. Because viral loads were measured by different assays at different institutions, interpatient comparisons should not be made. In (B) and (C), elevated AdV loads are detected in both blood (B) and stool (C) in a patient (#59) whose infection resolved after VST infusion. Results are expressed as copies per milliliter. (D) Frequency of AdV-directed T cells in peripheral blood before and at weeks 1, 2, 4, and 6 postinfusion, as measured with an IFN-γ ELIspot assay after overnight stimulation of PBMCs with Adv pepmixes (Hexon and Penton). Results are expressed as mean (±SD) SFCs per 2 × 105 input cells.
