Different levels of inflammatory cytokines are detected in LCMV-infected Stx11^−/−, Rab27a^−/−, and Prf1^−/− mice.Stx11^−/− (open bars/open squares), Rab27a^−/− (light gray bars/gray triangles), Prf1^−/− (dark gray bars/gray circles), and control B6 (black bars/black squares) mice were infected with 200 pfu of LCMV-WE. (A) The time course of serum IFN-γ production. ***P < .001 for control B6 versus Stx11^−/− and Rab27a^−/− versus Prf1^−/− at day 8. ***P < .001 for Stx11^−/− versus Rab27a^−/− and Stx11^−/− versus Prf1^−/− at day 8. ***P < .001 for Rab27a^−/− versus Prf1^−/− at day 8. (B) Serum IL-1β (left panel) and TNF-α levels (right panel) on day 12 after infection. (C) The time course of serum CXCL10 production. (D) Correlation between serum levels of IFN-γ and CXCL10 on day 8 after infection. (E) CXCL10 mRNA in spleen of infected mice. **P < .001. (F) Hematoxylin and eosin staining of representative spleen sections of control B6 (left panel) and STX11^−/− (right panel) mice 3 weeks after LCMV infection. (G) FACS analysis of spleen cells from control B6 (left panel) and Stx11^−/− (right panel) mice 3 weeks after LCMV infection, gated on I-Ab⁺ cells. Data (mean ± SEM) are representative of 3 independent experiments with at least 3 mice in each group.