Figure 3
LCMV-infected Stx11−/−, Rab27a−/−, and Prf1−/− mice display phenotypic manifestations of HLH of variable intensity.Stx11−/− (open bars/open squares), Rab27a−/− (light gray bars/gray triangles), Prf1−/− (dark gray bars/gray circles), and control B6 (black bars/black squares) mice were infected with 200 pfu of LCMV-WE. Clinical and biochemical parameters were determined after infection. (A) Survival, body weight, and body temperature. Survival was analyzed with a log-rank test (n = 12-16). *P < .05. ***P < .001. (B) White blood cell counts. ***P < .001. (C) Red blood cell and platelets counts. ***P < .001. (D) The time course of neutrophil counts. ***P < .001. (E) Serum aspartate aminotransferase (ASAT) and LDH levels in infected mice were analyzed on days 8, 12, and 20 after infection. **P < .01. ***P < .001. Data (mean ± SD) are representative of 4 independent experiments with at least 3 mice in each group.

LCMV-infected Stx11−/−, Rab27a−/−, and Prf1−/− mice display phenotypic manifestations of HLH of variable intensity.Stx11−/− (open bars/open squares), Rab27a−/− (light gray bars/gray triangles), Prf1−/− (dark gray bars/gray circles), and control B6 (black bars/black squares) mice were infected with 200 pfu of LCMV-WE. Clinical and biochemical parameters were determined after infection. (A) Survival, body weight, and body temperature. Survival was analyzed with a log-rank test (n = 12-16). *P < .05. ***P < .001. (B) White blood cell counts. ***P < .001. (C) Red blood cell and platelets counts. ***P < .001. (D) The time course of neutrophil counts. ***P < .001. (E) Serum aspartate aminotransferase (ASAT) and LDH levels in infected mice were analyzed on days 8, 12, and 20 after infection. **P < .01. ***P < .001. Data (mean ± SD) are representative of 4 independent experiments with at least 3 mice in each group.

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