Formation of cerebral brain infarction and neurologic deficits were tested in the tMCAO model. (A) Brain infarct volumes in control and platelet-depleted mice 24 hours after 60-minute tMCAO are represented as mean ± standard deviation. n.s., not significant; *P < .05; **P < .01; ***P < .001. (B) Representative images of 4 corresponding coronal brain sections from control and platelet-depleted mice stained with 2,3,5-triphenyltetrazolium chloride 24 hours after tMCAO. (C) Grip test and (D) Bederson score were determined 24 hours after tMCAO.