Tail bleeding time assay with control mice and mice with reduced platelet counts. One millimeter of the tail tip was cut off, and bleeding into 37°C prewarmed saline was monitored over a 20-minute time period. The horizontal line indicates the mean value to occlusive plug formation. Each symbol represents 1 animal (n.s., not significant; *P < .05; **P < .01; ***P < .001).