Ischemic brain damage area and bleeding. (A) Preinjury protocol. (B) Immediate postinjury protocol. (C) Left: early postinjury protocol; right: delayed postinjury protocol. Guinea pigs treated with vehicle (□), ALX-0081 (shaded square), rtPA, tirofiban, and ALX- 0081 + rtPA (▪). Data are reported as percentage of damaged brain area vs total brain area. Intracerebral hemorrhage as assessed by Hb content in the damaged hemisphere vs healthy hemisphere. (D) Immediate postinjury protocol. (E) Delayed postinjury protocol; data are reported as the difference in absolute amount of Hb between control and damaged hemisphere, expressed in mg/mL (mean ± standard deviation). (F) Skin bleeding time. *Outside the column P < .05 vs vehicle; inside the column P < .05 vs tirofiban. n = 5 per group.