Sequence analysis of Ldb1 complex–bound DNA fragments. (A) (Upper) Number of Ldb1 complex–bound fragments with GATA and/or E-box (CANNTG) motifs. (Lower) Consensus GATA motif within Ldb1 complex–bound DNA fragments discovered by MEME de novo motif search. (B) Number of Ldb1 complex binding sites that contain paired CANNTG/GATA motifs separated by 0-20 bp. Dotted line represents the expected number of peaks (binding sites) in randomly selected sites. Numbers in the plot represent P values of bars denoting fragments with the indicated number of base pairs separating the CANNTG and GATA motifs. (C) Consensus logo generated from the top 1000 Ldb1 complex binding sites. (D) Number of Ldb1 complex binding sites that contain paired TG/GATA motifs separated by 0-20 bp. Dotted line represents the expected number of peaks (binding sites) in randomly selected sites. Numbers in the plot represent P values of bars denoting fragments with the indicated number of base pairs separating the TG and GATA motifs. (E) Average Ldb1, Tal1, and Gata1 ChIP-Seq tag numbers for Ldb1 complexes bound to sites containing CANNTG from 7-11 bp 5-prime of a GATA. (F) Average Ldb1, Tal1, and Gata1 ChIP-Seq tag numbers for Ldb1 complexes bound to sites containing TG from 7-11 bp 5-prime of a GATA.