Patients with asymptomatic myeloma received lenalidomide and autologous, α-GalCer–loaded DCs to stimulate NKT cells. While a reduction of NKT cells was observed in peripheral circulation, expansion of eosinophils and natural killer cells was observed. CD16 expression was increased on CD14(+) monocytes and natural killer cell expression of NKG2D was also increased. Evidence to suggest SOX2-directed T-cell immunity was also observed.