Figure 1
![Figure 1. Distribution of mutations in SF3B1. Mutations in SF3B1 predominantly localize to its C-terminal domain between the fifth and eighth HEAT repeats (exons 14-16). (A) The accumulated mutation sites and frequencies from 5 published CLL sequencing studies. (B) The mutation sites and frequencies reported from other types of cancers (retrieved from COSMIC [version 62]). Rare mutations outside of the fifth to eighth HEAT repeats are not shown.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/121/23/10.1182_blood-2013-02-427641/4/4627f1.jpeg?Expires=1724233170&Signature=t79S9IBBO26bP4CNvxWC29ku9pKHpcneWpPpD~DuoKlq33B5MssJPSPW6xJhmZz~9UI9pyjwgfBXwXScJ7gb6LRzHfMN2R5ZCJkSsBB1~VXnYVlvq1vdZFmkayhMVfRMQztgpriHxObMwJjNHpKzXBv083YXXuHs~aGnJ39mjSfO1sML-UaTX9VkIXYhcydbj8427kv1BG6pLW980fkHLzzMih0VuPTxYQ-NLmVFaL3sqhXtIBn4OZymPEZyB18pZOSEuOgVrPU6JzhEsv7ZktVBCl69dHrEgByQEwyU9ZXarUWl5uGF~jumgzjkg37swalbk7XVfwItLR5rRrIeXQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Distribution of mutations in SF3B1. Mutations in SF3B1 predominantly localize to its C-terminal domain between the fifth and eighth HEAT repeats (exons 14-16). (A) The accumulated mutation sites and frequencies from 5 published CLL sequencing studies. (B) The mutation sites and frequencies reported from other types of cancers (retrieved from COSMIC [version 62]). Rare mutations outside of the fifth to eighth HEAT repeats are not shown.
