Figure 2
![Figure 2. PARP1 inhibition suppresses SSA- as well as NHEJ-mediated translocations. (A) The p5pF translocation reporter system has puro and alu repeats (hatched and black boxes) flanking I-SceI sites on chromosomes 14 and 17. A translocation mediated by NHEJ reconstitutes a functional neo gene on der[17], whereas SSA reconstitutes both neo on der[17] and a functional puro gene on der[14]. SSA-mediated translocation events confer neo and puro resistance, whereas NHEJ translocations confer only neo resistance. (B) Frequencies of SSA- and NHEJ-mediated translocations are averages (± SEM) for 3 determinations. *P < .05; **P < .01. All results were normalized for survival in inhibitors.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/121/21/10.1182_blood-2012-10-460527/4/4359f2.jpeg?Expires=1724956774&Signature=wsg-~TU2jHqW3C2QtWeg44cstJj0kBo8ChF1DTOWXgHI3BZYX4RNJ5znENNpG9dKn-SsSvJFODnz3ANV~Tav0-q8zvxTBE9NpnNN7Hw6p0FdKZ0mzzxmXnWnahnpQxXWp-5ejxYgDJA3pFc3yK4QdMP5Q6RmrhvAlnFAnxoLH1gG6ESoE4ELmEptG7Od8GUZ6eYhm9s7YQ-1SyIFt4jCK-xurRMrefeaRU9p1Du6HViIGaqc67bSGejSF304hj9tpO0RAf6M1P15cb8dRdcAzddepAAeoYewvsglNk~bDxWfdjr0hm6a4rSpgHdmBpMCqSLwg9vhSZpJnQYKJkWkWw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PARP1 inhibition suppresses SSA- as well as NHEJ-mediated translocations. (A) The p5pF translocation reporter system has puro and alu repeats (hatched and black boxes) flanking I-SceI sites on chromosomes 14 and 17. A translocation mediated by NHEJ reconstitutes a functional neo gene on der[17], whereas SSA reconstitutes both neo on der[17] and a functional puro gene on der[14]. SSA-mediated translocation events confer neo and puro resistance, whereas NHEJ translocations confer only neo resistance. (B) Frequencies of SSA- and NHEJ-mediated translocations are averages (± SEM) for 3 determinations. *P < .05; **P < .01. All results were normalized for survival in inhibitors.
