Changes in monocyte activation, neutrophil levels, and plasma LPS levels during maraviroc intensification. Changes in plasma sCD14 (A), sCD163 levels (B), peripheral blood absolute neutrophil counts (C), rectal tissue myeloperoxidase density (a surrogate marker for neutrophil density) (D), and plasma LPS levels (E) are plotted over time for both maraviroc-treated (red) and placebo-treated subjects (blue). Mean changes from baseline (A-B) or estimated mean values (C-E) with 95% CI from linear mixed models are plotted. P values are provided for the changes within each indicated interval both within arms and between arms. Given more frequent observations, changes in peripheral blood neutrophil counts were modeled as a linear spline with a change point at week 24.