Changes in the frequency of CCR5+ T cells and plasma MIP-1β levels during maraviroc intensification. Changes in the % CCR5+ CD8+ T cells (A) and CD4+ T cells (B) in peripheral blood, the % CCR5+ CD4+ T cells in rectal tissue (C), and plasma levels of the CCR5 ligand MIP-1β (D) were assessed in placebo-treated (blue) and maraviroc-treated (red) subjects with linear mixed models. Estimated mean values are plotted over time with 95% CIs. P values are provided for the changes within each indicated interval both within arms and between arms.