Changes in peripheral blood and rectal T-cell activation during maraviroc intensification. Estimated mean changes (with 95% CI) in the frequency of activated (CD38+HLA-DR+) CD4+ (A) and CD8+ (B) T cells in peripheral blood are plotted for placebo-treated (blue) and maraviroc-treated (red) subjects. Estimated mean changes (with 95% CI) in the frequency of activated CD4+ (C) and CD8+ (D) T cells in rectal tissue are also plotted for both arms. P values are provided for the changes within each indicated interval both within arms and between arms.