Clinical impact of the genotype in stereotyped BCR subset 2 and subset 8 CLL. (A) Kaplan-Meier estimates of TFS according to SF3B1 mutation status in CLL utilizing the IGHV3-21 gene. (B) Heat map showing the relationship between genetic lesions and Richter syndrome transformation in subset 8 CLL. Rows correspond to identical variables, and columns represent individual patients color-coded based on the molecular status (white, absence of the variable; red, presence of the variable).