Distribution of CLL driver genetic lesions across major stereotyped BCR subsets. (A) Circos plot representing the relative frequency and pairwise co-occurrence of CLL driver genetic lesions and usage of stereotyped BCR belonging to majors subsets (1, 2, 3, 4, 5, 6, 7B, and 8) in newly diagnosed CLL. The length of the arc corresponds to the frequency of the genetic lesions. The width of the ribbon corresponds to the percentage of patients in which the 2 connected variables co-occur. (B) Prevalence of CLL driver genetic lesions within the major BCR subsets (1, 2, 3, 4, 5, 6, 7B, and 8) in newly diagnosed CLL. p, P value from the nonparametric binomial test; p corrected, P value from the nonparametric binomial test corrected for multiple hypothesis testing.