Liver disease and histopathological alterations in pearl mice undergoing LCMV-induced HLH.C57BL/6, pearl, pearl-ash^+/−, ashen, and PKO mice were infected with LCMV-WE and 8 days later, serum levels of (A) GPT, LDH, and triglycerides (TG) were determined. (B) Splenomegaly was analyzed by calculating spleen weight in percent of body weight. (C) Representative liver sections stained with anti-F4/80 (original magnification, 10×) obtained at day 8 after infection. Lower left inset: semiquantitative analysis of hemophagocyting macrophages as assessed in 10 high-power visual fields (40×) per mouse. (+) indicates rare; +, few; and ++, frequent. Scale bars represent 100 µm. n.s. indicates not significant (P > .05); *P < .05; **P < .01.