Figure 4
Figure 4. Inhibition of tumor relapse by adoptive transfer of allogeneic anti–third-party Tcm. Lethally irradiated (8Gy TBI) BALB/c (H-2d) mice received an intravenous transplant of 3 × 106 allogeneic TDBM cells (B6 nude [H-2b]) in the presence or absence of 5 × 103A20-luc lymphoma cells (day 0). Mice were then (day +1) intravenously injected with 5 × 106 B6-derived anti–third-party Tcm (A20+ Allo Tcm; n = 7) or left untreated (A20 only; n = 8). (A) Tumor growth was monitored by BLI from day 13 at weekly intervals. (B) Survival rates of the animals in the different treatment groups are shown.

Inhibition of tumor relapse by adoptive transfer of allogeneic anti–third-party Tcm. Lethally irradiated (8Gy TBI) BALB/c (H-2d) mice received an intravenous transplant of 3 × 106 allogeneic TDBM cells (B6 nude [H-2b]) in the presence or absence of 5 × 103A20-luc lymphoma cells (day 0). Mice were then (day +1) intravenously injected with 5 × 106 B6-derived anti–third-party Tcm (A20+ Allo Tcm; n = 7) or left untreated (A20 only; n = 8). (A) Tumor growth was monitored by BLI from day 13 at weekly intervals. (B) Survival rates of the animals in the different treatment groups are shown.

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