Figure 3
Figure 3. Inhibition of tumor relapse by syngeneic anti–third-party Tcm after syngeneic BMT. Lethally irradiated (8Gy TBI) BALB/c mice (H-2d) received an intravenous transplant of 3 × 106 syngeneic T-depleted BM cells (BALB/c nude [H-2d]) in the presence or absence of 5 × 103A20-luc lymphoma cells (day 0). On the following day, mice were intravenously injected with 10 × 106 (n = 7) or 2 × 107 (n = 5) BALB/c-derived anti–third-party Tcm or left untreated (A20 only) (n = 7). (A) Tumor growth was monitored by BLI from day 14 at weekly intervals. (B) Survival curves of the animals from the various treatment groups are shown.

Inhibition of tumor relapse by syngeneic anti–third-party Tcm after syngeneic BMT. Lethally irradiated (8Gy TBI) BALB/c mice (H-2d) received an intravenous transplant of 3 × 106 syngeneic T-depleted BM cells (BALB/c nude [H-2d]) in the presence or absence of 5 × 103A20-luc lymphoma cells (day 0). On the following day, mice were intravenously injected with 10 × 106 (n = 7) or 2 × 107 (n = 5) BALB/c-derived anti–third-party Tcm or left untreated (A20 only) (n = 7). (A) Tumor growth was monitored by BLI from day 14 at weekly intervals. (B) Survival curves of the animals from the various treatment groups are shown.

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