Figure 3
Figure 3. Hepatic function tests for 5 patients. There are 5 reports of hepatic function tests for 5 different patients. Each report contains 2 columns of information in the following order: a scale for days in relation to the HCT and the measured values for each test. Name and reference range for each test is provided in the top row of each report. Laboratory values between days −24 and −10 before HCT were the only values considered for evaluation of hepatic comorbidity. The elevated laboratory value that was closest to day −10 was used for assigning the severity score; it was highlighted in yellow. The red asterisk (*) means values were outside the reference range. (A) This patient had 2 normal values of ALT at days −17 and −14 before HCT. No score was assigned to the ALT portion of hepatic comorbidity for this patient. (B) This patient had only 3 values of ALT between days −24 and −10 before HCT; 2 values were normal and the other value was elevated. Even though this patient had multiple elevated values of ALT after day −10, no score was assigned for the ALT portion of hepatic comorbidity because the patient did not have 2 elevated values of ALT between days −24 and −10. (C) This patient had 1 normal and 2 elevated values of AST between days −22 and −12 before HCT. The maximal score, a score of 3, was assigned for hepatic comorbidity in this patient because the closest elevated value of AST to day −10 was 105 U/L, which was more than 2.5 times the ULN for AST based on the reference range. Note that the values after day −12 did not contribute to the evaluation of this comorbidity. (D) This patient had 1 normal and 4 elevated values of AST between days −21 and −10 before HCT. A score of 1 was assigned to the AST portion for hepatic comorbidity in this patient, given that the closest elevated value of AST to day −10 was 44 U/L, which was less than 2.5 the ULN for AST. A score of 1 was assigned despite normalization of AST values after day −10. A complete evaluation of other hepatic laboratory tests (ALT and bilirubin) was still required before a decision is made on the maximal score to be assigned for hepatic comorbidity in this patient. (E) This patient had multiple elevated values of total bilirubin between days −24 and −10 before HCT. A score of 1 was assigned for the bilirubin portion of hepatic comorbidity in this patient because the value of total bilirubin at day −10 was 1.9 mg/dL (<2.5 the ULN for total bilirubin). A complete evaluation of other hepatic laboratory tests (ALT and AST) was required before a decision is made on the maximal score to be assigned for hepatic comorbidity in this patient.

Hepatic function tests for 5 patients. There are 5 reports of hepatic function tests for 5 different patients. Each report contains 2 columns of information in the following order: a scale for days in relation to the HCT and the measured values for each test. Name and reference range for each test is provided in the top row of each report. Laboratory values between days −24 and −10 before HCT were the only values considered for evaluation of hepatic comorbidity. The elevated laboratory value that was closest to day −10 was used for assigning the severity score; it was highlighted in yellow. The red asterisk (*) means values were outside the reference range. (A) This patient had 2 normal values of ALT at days −17 and −14 before HCT. No score was assigned to the ALT portion of hepatic comorbidity for this patient. (B) This patient had only 3 values of ALT between days −24 and −10 before HCT; 2 values were normal and the other value was elevated. Even though this patient had multiple elevated values of ALT after day −10, no score was assigned for the ALT portion of hepatic comorbidity because the patient did not have 2 elevated values of ALT between days −24 and −10. (C) This patient had 1 normal and 2 elevated values of AST between days −22 and −12 before HCT. The maximal score, a score of 3, was assigned for hepatic comorbidity in this patient because the closest elevated value of AST to day −10 was 105 U/L, which was more than 2.5 times the ULN for AST based on the reference range. Note that the values after day −12 did not contribute to the evaluation of this comorbidity. (D) This patient had 1 normal and 4 elevated values of AST between days −21 and −10 before HCT. A score of 1 was assigned to the AST portion for hepatic comorbidity in this patient, given that the closest elevated value of AST to day −10 was 44 U/L, which was less than 2.5 the ULN for AST. A score of 1 was assigned despite normalization of AST values after day −10. A complete evaluation of other hepatic laboratory tests (ALT and bilirubin) was still required before a decision is made on the maximal score to be assigned for hepatic comorbidity in this patient. (E) This patient had multiple elevated values of total bilirubin between days −24 and −10 before HCT. A score of 1 was assigned for the bilirubin portion of hepatic comorbidity in this patient because the value of total bilirubin at day −10 was 1.9 mg/dL (<2.5 the ULN for total bilirubin). A complete evaluation of other hepatic laboratory tests (ALT and AST) was required before a decision is made on the maximal score to be assigned for hepatic comorbidity in this patient.

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