BCL6 translocation breakpoints in human B-cell lymphomas. The top 3 tracks in this University of California, Santa Cruz, Genome Browser snapshot show the 2156-bp BCL6 break window defined in this study (red), the location of BCL6 breaks analyzed here (black), and the H3K4me3 chromatin immunoprecipitation–seq read density in the lymphoma cell line OCI-Ly1 (blue). The fourth track shows exons 1 to 11 of the BCL6 gene (rectangles), with exon 1 at the far right. Exons 1, 2, 3, and parts of exons 4 and 11 are untranslated. The red line in the bottom panel is a magnified view of the 2156-bp break window within BCL6 intron 1. The numbering corresponds to human chromosome 3q (NCBI36/hg 18). The open triangles denote BCL6 breaks in IgH–BCL6 translocations, the gray triangles denote BCL6 breaks in IgL translocations (11 λ and 1 κ), and the filled black triangles denote BCL6 breaks in non-Ig translocations.