Bubble plot representation of Ldb1-binding peaks around differentially regulated developmental hematopoietic/endothelial genes in Ldb1^−/− BL-CFCs. Each bubble in the plot represents one Ldb1-binding peak allocated to a hematopoietic-specific gene (purple bubble), an endothelial-specific gene (yellow bubble), or a gene involved in both hematopoietic and endothelial development (red bubble). The distance of each binding peak relative to a transcription start site of each gene is represented on the x-axis, whereas changes in gene expression in the Ldb1^−/− vs Ldb1^+/+ Flk1⁺ cells are represented on the y-axis as the log2fold change. The height of the binding signal/peak is represented by the diameter of the bubble. Hematopoietic- and endothelial-specific genes were identified through the use of IPA (Ingenuity Systems, www.ingenuity.com) and showed a 13.67% (29 of 212 genes) overlap, with the subset of endothelial genes identified through the study of Takase et al.³⁹  The lists of hematopoietic- and endothelial-specific genes, as well as the common hematopoietic/endothelial genes, used to generate the plot are provided in supplemental Table 2.