Figure 4
Figure 4. Bubble plot representation of Ldb1-binding peaks around 4 selected hematopoiesis-specific genes downregulated in the Ldb1−/− BL-CFCs. Each of the figures (A-D) are divided into three panels. The upper panel shows the studied gene and the neighboring genomic genes. The middle panel shows the differential expression (presented as log2fold change on the y-axis) of the studied gene in Ldb1−/− Flk1+ cells in correlation with the Ldb1-binding peaks identified within or around the gene body. The light gray circles (allocated to binding peaks) represent downregulation of gene expression. On the bottom panel, ChIP binding peak heights are represented on the y-axis and genome location on the x-axis. The dark gray color represents Ldb1 ChIP peaks and the black color represents IgG ChIP peaks (used as control).

Bubble plot representation of Ldb1-binding peaks around 4 selected hematopoiesis-specific genes downregulated in the Ldb1−/− BL-CFCs. Each of the figures (A-D) are divided into three panels. The upper panel shows the studied gene and the neighboring genomic genes. The middle panel shows the differential expression (presented as log2fold change on the y-axis) of the studied gene in Ldb1−/− Flk1+ cells in correlation with the Ldb1-binding peaks identified within or around the gene body. The light gray circles (allocated to binding peaks) represent downregulation of gene expression. On the bottom panel, ChIP binding peak heights are represented on the y-axis and genome location on the x-axis. The dark gray color represents Ldb1 ChIP peaks and the black color represents IgG ChIP peaks (used as control).

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