Figure 2
Meta-analysis of GWAS in CEU, YRI, ASW, and ASN populations. (A) The Manhattan plot shows the meta-analysis results on GWAS of cellular susceptibility to cytarabine in 4 world populations (n = 523 individual samples). The highest-ranked SNP was rs7729269 (P = 3.67 × 10−7) in the gene MCC. (B) The plot shows P values from the meta-analysis of GWAS in CEU, YRI, ASW, and ASN populations for the top SNP associations with cytarabine log2 AUC in a specific region on chromosome 5. The colors, as indicated in the legend, denote the extent of LD between the SNPs; for this purpose, we use only the CEU reference population. The bottom panel illustrates the chromosomal region and genes that these SNPs fall on. The figure was made in LocusZoom.

Meta-analysis of GWAS in CEU, YRI, ASW, and ASN populations. (A) The Manhattan plot shows the meta-analysis results on GWAS of cellular susceptibility to cytarabine in 4 world populations (n = 523 individual samples). The highest-ranked SNP was rs7729269 (P = 3.67 × 10−7) in the gene MCC. (B) The plot shows P values from the meta-analysis of GWAS in CEU, YRI, ASW, and ASN populations for the top SNP associations with cytarabine log2 AUC in a specific region on chromosome 5. The colors, as indicated in the legend, denote the extent of LD between the SNPs; for this purpose, we use only the CEU reference population. The bottom panel illustrates the chromosomal region and genes that these SNPs fall on. The figure was made in LocusZoom.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal