Working model of Mi2β-mediated developmental globin gene silencing through multiple mechanisms. Mi2β is a critical component of the MBD2/NuRD complex that regulates developmental globin gene silencing independently of BCL11A and KLF1-EKLF in an indirect manner. Mi2β binds to the distal promoter region of the γ-globin gene as part of the MBD3/NuRD/GATA-1/FOG-1 silencing complex. Mi2β binds to and activates expression of BCL11A and KLF1/EKLF, which in turn silence γ-globin gene expression. Solid arrows represent direct interactions, and dotted arrows represent indirect interactions.