Estimated probability of early death for each day delaying chemotherapy initiation. The graph shows the estimated probability of early death for each value of TDT, adjusted* for the mean of all other variables of the model. The locations of the 3 knots used in the RCS method are 1, 8, and 32 days (corresponding, respectively, to the 10th, 50th, and 90th percentile of the TDT).²²  *Adjusted for age (odds ratio [OR] = 2.41; 95% CI: 1.32-4.39; P = .004 for subjects >60 vs ≤60 years), ECOG performance status (OR = 1.87, 95% CI: 0.70-4.99, P = .213; OR = 3.23, 95% CI: 1.07-9.74, P = .037; and OR = 8.40, 95% CI: 2.20-32.0, P = .002, respectively, for ECOG 1, 2, and 3/4 vs 0), secondary AML (OR = 2.84; 95% CI: 1.48-5.46; P = .002 compared with de novo AML), WBC (OR = 4.48; 95% CI: 2.11-9.52; P < .001) for subjects >50 vs ≤50 G/L), and ELN classification (OR = 1.42, 95% CI: 0.56-3.62, P = .458; OR = 1.83, 95% CI: 0.71-4.71, P = .208; and OR = 0.78, 95% CI: 0.26-2.34, P = .659, respectively, for intermediate I, intermediate II, and adverse vs favorable).