Estimated HR of death for each day delaying chemotherapy initiation. (A) RCS method shows the nonadjusted HR of death for each value of TDT compared with day 6. For example, the nonadjusted HR of death for a TDT of 1 day is equal to 1.38 (95% CI: 1.03-1.86) compared with day 6 according to the RCS method. The locations of the 4 knots used in the RCS method are 1, 5, 12, and 42 days (corresponding, respectively, to the 5th, 35th, 65th, and 95th percentile of the TDT).²²  (B) RCS method shows the adjusted* estimated hazard ratio of death for each value of TDT compared with day 6. *Adjusted for age (HR = 1.36; 95% CI: 1.08-1.70; P = .008 for subjects >60 vs ≤60 years), ECOG performance status (HR = 1.46, 95% CI: 1.12-1.91, P = .006; HR = 1.76, 95% CI: 1.22-2.53, P = .002; and HR = 1.73, 95% CI: 0.97-3.07, P = .062, respectively, for ECOG 1, 2, and 3/4 vs 0), secondary AML (HR = 1.51; 95% CI: 1.18-1.93; P = .001 compared with de novo AML), WBC (HR = 1.59; 95% CI: 1.18-2.15; P = .002 for subjects >50 vs ≤50 G/L), ELN classification (HR = 2.29, 95% CI: 1.61-3.24, P < .001; HR = 2.79, 95% CI: 1.98-3.94, P < .001; and HR = 3.86, 95% CI: 2.69-5.55, P < .001, respectively, for intermediate I, intermediate II, and adverse vs favorable), and consolidation (HR = 0.47, 95% CI: 0.30-0.76, P = .002 and HR = 0.63, 95% CI: 0.45-0.88, P = .007, respectively, for autologous stem cell transplantation and allogeneic stem cell transplantation vs high-dose cytarabine only).