Stem cell signatures in AML converge on a core set of signaling pathways. (A) Venn diagram showing the overlap of genes between the Heptad targets and the P-SCE and LSC-R/HSC-R signatures. (B) Venn diagram showing the overlap of pathways in which the P-SCE-sig genes, Heptad target genes,¹¹  and the LSC-R and HSC-R genes³  are significantly represented. The 106 shared pathways were ranked based on whether the component genes in a pathway were differentially expressed between AML patients in the short and long survival groups in Figure 5A; the highest ranked pathways are listed. Also see supplemental Figure 8.