Proposed model linking early clonal dominance with granulomonocytic skewing of immature progenitors in CMML. According to their stage of expansion (early in CMML, later in other chronic myeloid neoplasms), TET2 mutations will or will not give rise to monocytosis. TET2-mutated cells are represented with dashed lines. Granulomonocytic differentiation potential is depicted in green, erythroid potential in red.