Fine-tuning vaccine formulations to tailor immune responses to diseases. Vehicle preparation from a choice of antigen, adjuvant, and targeting moieties, such as antibodies, results in versatile vaccine formulations. The combination of different vehicles in one vaccine allows not only for a controlled provision of antigen and adjuvant to the targeted cell subsets, but also for tailoring of Th1, Th2, and type I interferon responses to meet the needs for treatment of specific diseases.