Impact of mutated GATA2 on human NK cell subsets and function. GATA2 is expressed highly in CD56^bright NK cells, and expression is decreased in mature CD56^dim NK cells. Most patients with GATA2 mutations, thought to result in GATA2 loss of function, have almost complete absence of CD56^bright NK cells and greatly reduced overall NK cell numbers. The residual CD56^dim NK cells are not enabled for effective cytotoxicity, whereas other NK cell functions remain to be investigated. Patients with GATA2 mutations have recurrent viral infections, especially human papilloma virus and herpesviruses. ADCC: antibody dependent cellular cytotoxicity.