Model predictions on IM treatment cessation. (A) BCR-ABL transcript levels under IM treatment of patient subgroup predicted not to relapse after discontinuation of IM therapy. (B) BCR-ABL transcript levels under IM treatment of patients predicted to molecularly relapse after treatment cessation. Note that panels A and B divide the kinetics shown in Figure 1B into 2 subsets. (C) Relationship between ratio of first to second declines and number of residual LSCs at the moment of treatment cessation. Data points represent patients who are predicted not to relapse (green triangles) or to relapse (red circles) molecularly. Dashed lines represent predictors that allow for discrimination between patient subgroups (see “Model predictions on treatment discontinuation”). Note that both axes are log-transformed.