Model prediction on IM treatment cessation after fixed treatment time of 2 years in MR^5.0 in comparison to survival curves from 2 actual IM discontinuation trials. Shown are Kaplan-Meier estimates of time to molecular relapse after discontinuation of therapy. The solid line shows a model prediction for 42 of 51 patients from the IRIS trial that reached a sustained MR^5.0 for 2 consecutive years less than 20 years after initiation of IM therapy. Whereas the dotted line corresponds to the results from a French trial,¹⁸  the dashed line shows the survival curve from an Australian trial.¹⁷  For details see “Model predictions on treatment discontinuation.”