Model predictions for representative individual patient. (A) Data points (BCR-ABL transcript levels) obtained by qRT-PCR are represented by filled circles connected by black lines. The corresponding computer simulation is depicted by the gray line. (B) Model prediction from panel A extended to 30 years. The vertical line corresponds to the latest follow-up time point. Gray boxes in panels A and B represent detection threshold of BCR-ABL levels. (C) Corresponding absolute number of residual LSCs of the simulation results depicted in panel B. Continuous IM administration is required for approximately 30 years until complete eradication of LSCs is predicted for this particular patient. To account for quantitative differences between simulations because of the model-inherent stochasticity, 5 simulation runs using identical parameter values are performed and averaged.