Results of the application of the biphasic regression procedure to clinical data from the German cohort of the IRIS trial. (A) Example of an individual patient. Data points obtained by qRT-PCR are represented by filled circles connected by black lines. The result of the least squares algorithm is depicted by the gray line. (B) Overview of regression results of all 51 patients characterized by a biphasic decline. The gray boxes in panels A and B represent the detection threshold of BCR-ABL transcripts levels.