Failure-free survival after second-line treatment of chronic GVHD (from Inamoto et al). The black area represents treatment failure due to onset of third-line systemic treatment, the dark gray area represents treatment failure due to recurrent malignancy, the light gray area represents treatment failure due to nonrelapse mortality (NRM), and the white area represents failure-free survival (FFS). The dashed line represents cumulative incidence of successful withdrawal of all systemic immunosuppressive treatment (IST) during second-line treatment. See Figure 1 in the article by Inomata et al that begins on page 2340.