Regulation of megakaryopoiesis by Ikaros, Notch, and GATA-1. Findings from Malinge et al1 indicate that Ikaros controls megakaryocyte development both by inhibiting Notch signaling and by repressing multiple megakaryocyte differentiation genes, including GATA-1. Conversely, GATA-1 downregulates Ikaros expression. See Figure 7 in the article by Malinge et al that begins on page 2440.
