Model of megakaryopoiesis proposed by Miyawaki et al. Megakaryocyte production in human bone marrow proceeds through a unilineage MegP progenitor that can be purified within the classic CMP compartment as CD34⁺ CD38⁺ CD45RA⁻ IL-3Rα^dim CD41⁺. In patients with JAK2 V617F mutated essential thrombocythemia, the MegP population is expanded and may contribute to disease pathology. EryP, unipotent erythrocyte progenitor; GMP, granulocyte-macrophage progenitor. The figure has been adapted from Figure 7 in the article by Miyawaki et al that begins on page 3332.