Schema of clonal relatedness in AML cases (paired enrollment and persistent disease samples) inferred from genomic profiling data. The quantitatively dominant clone as detected at the time of analysis is circled in green. AC: inferred antecedent clone. T_E: enrollment sample, T_P: paired persistent disease sample. Arrows indicate possible routes of clonal evolution. Circles indicate gene mutations, rectangles indicate aCNA or cnLOH.