Figure 6
Figure 6. Residual collagen-/thrombin-induced PS exposure in Scott syndrome platelets is insensitive to Q-VD-Oph or cyclosporin A (CsA). Annexin (Anx) A5 binding (A) and TMRE loss (B) of washed control and Scott syndrome platelets stimulated by collagen (Col)/thrombin (Thr) (10 μg/mL, 4 nM) for 15 min in the presence of 2 mM CaCl2 preincubated with vehicle (dimethylsulfoxide), Q-VD-Oph (20 μM), or CsA (4 μM) for 10 min. Mean ± SEM (n = 3-6); *P < .05.

Residual collagen-/thrombin-induced PS exposure in Scott syndrome platelets is insensitive to Q-VD-Oph or cyclosporin A (CsA). Annexin (Anx) A5 binding (A) and TMRE loss (B) of washed control and Scott syndrome platelets stimulated by collagen (Col)/thrombin (Thr) (10 μg/mL, 4 nM) for 15 min in the presence of 2 mM CaCl2 preincubated with vehicle (dimethylsulfoxide), Q-VD-Oph (20 μM), or CsA (4 μM) for 10 min. Mean ± SEM (n = 3-6); *P < .05.

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