MYC, BCL2, and BCL6 rearrangements and protein expression regarding cell of origin classification and their prognostic impact in patients with DLBCL treated by R-CHOP. MYC and BCL2 rearrangements were more frequently observed in GCB-DLBCL and BCL6 translocation was more frequently observed in non-GCB-DLBCL, whereas at the protein level, no significant difference with respect to MYC overexpression was noted between GCB- and non-GCB-DLBCLs. The survival analyses showed that, taken individually, MYC, BCL2, and BCL6 protein overexpression was associated with an adverse prognosis, independently of the IPI score. The pattern associating MYChigh, BCL2high, BCL6low, and MYC rearrangement was highly predictive of the prognosis, independent of the IPI score.