Basal and induced expression of CYP2B6, CYP3A4, ADHs, ALDHs, and CAR in hematopoietic cancer cells. Total RNA was extracted from 7 hematopoietic cancer cell lines, namely, HL-60, REH, K562, SUDHL4, SUDHL6, OCI-LY-3, and Farage, and primary lymphoma and leukemia cells from 4 patients (T-cell lymphoma [TCL1 and TCL2], and acute myeloid leukemia [AML1 and AML2]). (A) The relevant gene abundance of CYP2B6, CYP3A4, ADH1B, ADH1C, ALDH1A1, ALDH3A1, ALDH5A1, and CAR in these cells was analyzed using RT-PCR in comparison with that in HPHs from donor HL#7 and HL#10, as detailed in “Methods.” (B-C) HL-60 cells, TCL1, AML1, and HPHs (HL#20) were treated with CITCO (1μM), RIF (10μM), or vehicle control (0.1% DMSO) for 24 hours. Subsequently, inductive expression of CYP2B6, CYP3A4, and CAR in these cells was measured by RT-PCR. RT-PCR data obtained from 3 independent experiments were expressed as mean ± SD normalized against vehicle control (**P < .01).