MicroRNA regulate mRNA and protein expression in T cells. (A) A computational method to identify microRNA function and mRNA targets in T cells. Target genes of significantly regulated microRNA between ITP patients and controls, using TargetScan and Miranda algorithms, were compared with significantly regulated mRNA from peripheral blood T cells between patients and controls. Diamonds are microRNA and circles are mRNA. Red indicates up-regulated and blue indicates down-regulated genes. (B) Plasma levels of CXCL13, which was a significantly regulated target gene of a microRNA that differed in expression between ITP patients and controls, were significantly increased in plasma from patients with ITP compared with controls.