Transcription factors downstream of IRF8. (A) Expression levels of transcription factor genes upregulated by IRF8 more than 10-fold are displayed as a heatmap (also see supplemental Table 6). Genes bound by IRF8 are indicated in red. (B-C) Known DNA binding motif analysis for transcription factors in the 1-kb proximal regions upstream of TSSs (B) or the distal enhancer (H3K4me1) regions (C) of indirect IRF8 target genes or all other genes not bound by IRF8. The upper panels indicate the frequency of genes with these motifs. (*) P < .05 (χ² test). The lower panels indicate the Z-score.