FGFR1 inactivation impairs HSPC recovery after BM damage. (A) Comparison of LSK numbers in BM of Mx1:Control and Mx1:CKO mice at the indicated times after 5FU (n = 2-4). (B) Illustration of Cre induction, 5FU-induced BM damage, and analyses of Fgfr1 control (Cre⁻:Fgfr1^fx/fx) and CKO (Cre⁺:Fgfr1^fx/fx) mice. Polyinosinic:polycytidylic acid (pIpC). Tamoxifen (TMX). (C) Flow cytometric analyses of the LSK population and comparison of absolute numbers of LSK cells in BM from Mx1:Control, Mx1:CKO (n = 4), Scl:Control, Scl:CKO (n = 6), and Tek:Control, Tek:CKO (n = 6) mice 12 days after 5FU. (D) Flow cytometric analyses of the LSK population and comparison of absolute numbers of LSK cells in spleen from Mx1:Control, Mx1:CKO (n = 4), Scl:Control, Scl:CKO (n = 5), and Tek:Control, Tek:CKO (n = 6) mice 12 days after 5FU (*P < .05). Data pooled from at least 2 independent experiments.