HPC TF is required for early thrombin generation in mice given a hepatotoxic dose of APAP. Fasted control mice (TF^flox/flox mice) and HPC^ΔTF mice were treated with 300 mg/kg APAP. (A) Serum ALT activity and (B) plasma TAT levels were determined 2 h after APAP administration. Data are expressed as mean + SEM. *Significantly different from control mice (P < .05). n = 5 to 10 mice/group.