Identification of transcriptional targets of Sox4 in Ph⁺ ALL. We deleted Sox4 on an inducible activation of Cre in Sox4^fl/fl leukemia cells (supplemental Figure 1) and studied gene expression changes after 1 day of activation of Cre or an empty vector control (EV; A). Sox4-dependent gene expression changes (GSE36543) involve the PI3K/AKT, MAPK, and critical survival pathways. Target genes were verified in a qRT-PCR (B-C; supplemental Figure 3). In panel C, BCL2L1 is verified as Sox4 target gene in BCR-ABL1 ALL cells through Cre-mediated deletion and retroviral overexpression of Sox4.