Figure 4
![Figure 4. Genetics in T-PLL. (A) Complex karyotype from a case of T-PLL showing the characteristic abnormalities of inversion 14 and trisomy 8 [gain of whole chromosome rather than i(8q)]. The karyotype is 47,XX, +8, del12(p13.1p13.3), inv(14) (q11q32). (B) The deregulation of the oncogenes TCL-1 (chromosome 14) and MTCP-1(X chromosome) through translocations involving the TCR alpha locus on chromosome 14. Courtesy of John Swansbury (Royal Marsden Hospital).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/120/3/10.1182_blood-2012-01-380139/4/zh89991293820004.jpeg?Expires=1724234606&Signature=LIrV56jjEG6ssEuGIHsjUsYiwzlgvz8vddf3GgbToP6E-7rEzSLENcFMd34hWwUHJ4rdrZmh76XQNCKc3Fc-k-b8HhgWbaAvEE0wEpPt2ON~TI0LeS8jUyAAc3xHJhc2Eg3A0-IumESWDX~mnwT4~~tzu2SPbyCnlOnCBQaZF3rwqAOWhUTI4k6XD2Q8PpkK-2LDzrmcKyw8fQyrnr3q2a3gVQM56r18LQiYxyopw764AuJyrpWbYKUD-pZcs80ZH3I5XFLTywGofQEqe9r8qjp41sF5gQRI~Cu1pmK2AOX8uQ1LNIAIUqCBIc3pry1uQpNEMmhjCHepA78ODMG55Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Genetics in T-PLL. (A) Complex karyotype from a case of T-PLL showing the characteristic abnormalities of inversion 14 and trisomy 8 [gain of whole chromosome rather than i(8q)]. The karyotype is 47,XX, +8, del12(p13.1p13.3), inv(14) (q11q32). (B) The deregulation of the oncogenes TCL-1 (chromosome 14) and MTCP-1(X chromosome) through translocations involving the TCR alpha locus on chromosome 14. Courtesy of John Swansbury (Royal Marsden Hospital).
