Macrophage-derived VEGF controls vascular sprout induction during the early phase of tissue repair. Shown are CD31/Dll4 double immunostaining and morphometric quantification of wound tissue. Left, rectangle outlines vascular structures within granulation that are presented at higher magnification in images presented in the middle. Arrow indicates the tip of epithelial tongue; dotted line, hyperproliferative epithelial tongue; arrowheads, front of sprouting tips; he, hyperproliferative epithelium; and g, granulation tissue. Scale bar indicates 100 μm. Three independent experiments were performed and each dot represents 1 wound. *P < .05.